Redox Systems Biology of Nutrition and Oxidative Stress

Oxidative stress: a concept in redox biology and medicine

"Oxidative stress" as a concept in redox biology and medicine has been formulated in 1985; at the beginning of 2015, approx. 138,000 PubMed entries show for this term. This concept has its merits and its pitfalls. Among the merits is the notion, elicited by the combined two terms of (i) aerobic metabolism as a steady-state redox balance and (ii) the associated potential strains in the balance a...

Redox and Ionic Homeostasis Regulations against Oxidative, Salinity and Drought Stress in Wheat (A Systems Biology Approach)

Systems biology and omics has provided a comprehensive understanding about the dynamics of the genome, metabolome, transcriptome, and proteome under stress. In wheat, abiotic stresses trigger specific networks of pathways involved in redox and ionic homeostasis as well as osmotic balance. These networks are considerably more complicated than those in model plants, and therefore, counter models ...

Virtual issue by COST Action BM1203 (EU-ROS) “Emerging concepts in redox biology and oxidative stress”

The article by Bacic et al. [1] (link to http://dx.doi.org/10.1016/j. redox.2015.10.007) provides an overview on the application of magnetic resonance imaging (MRI) and electron paramagnetic resonance (EPR) spectroscopy of stable nitroxide radicals to monitor metabolically induced changes in the redox status of organs. These techniques will not only contribute to the mechanistic understanding o...

Oxidative stress-mediated HMGB1 biology

High mobility group box 1 (HMGB1) is a widely-expressed and highly-abundant protein that acts as an extracellular signal upon active secretion by immune cells or passive release by dead, dying, and injured cells. Both intracellular and extracellular HMGB1 play pivotal roles in regulation of the cellular response to stress. Targeting the translocation, release, and activity of HMGB1 can limit in...

Magnesium and Other Biometals in Oxidative Medicine and Redox Biology